The Endocannabinoid System-Part 2

Hey blogees, got your notebook? We are getting right back into the ECS. Don’t know what I’m talking about lol? Click here to catch up!

Picking right up where we left off in part one, there are two main receptors in the body that make up the endocannabinoid system. CB1 and CB2.  They are both G protein-coupled receptors. G protein-coupled receptors are messengers to cells, letting them know if there is or isn’t critical life or nutrients in their environments. Real Gs look out for their cell homies, feel me? Cannabinoids, especially THC, binds to these receptors to give the consumer relaxing, uplifting, or pain relieving effects (or all 3!)

CB1 is the primary receptor of the endocannabinoid system, and gets its cannabinoid binding on mainly in the brain, central nervous system, connective tissues, gonads, glands, and related organs. That means relief from pain, nausea, and depression!

CB2 receptors are also found in the brain, just not as densely as CB1. They are found in the immune systems and their related organs, including the spleen, tonsils, and thymus gland. Additionally, sites of CB2 binding  are found in larger densities in the gastrointestinal system. As a result, sufferers of Crohn’s disease have found relief and sometimes, full remission of the disease. Say whaaaa?

So when looking for cannabis, or researching methods of relief with cannabis, check your receptors!

References:

http://headsup.scholastic.com/students/endocannabinoid

https://en.wikipedia.org/wiki/Cannabinoid_receptor_type_2

https://www.massroots.com/learn/what-are-cannabinoid-receptors/

 

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